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The More Things Change, the More They Stay the Same
David Gibson,1 Kristen Hsu,1 James Signorovitch,2 and Isabelle Lousada1 1Amyloidosis Research Consortium, Newton, MA, USA; 2The Analysis Group Inc., Boston, MA, USA Amyloid transthyretin (ATTR) amyloidosis is a progressive, debilitating, and ultimately fatal disease caused by deposition of misfolded transthyretin (TTR) amyloid fibrils in multiple tissues and organs and the resultant organ dysfunction.1 The TTR protein can misfold in its native state to form wild-type ATTR (ATTTwt) amyloidosis or due to a mutation in the gene resulting in variant...
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