Hereditary ATTR Amyloidosis

In this ARC TALKS webinar Dr. Sara Horst, Professor of Medicine in the Division of Gastroenterology, Hepatology and Nutrition at Vanderbilt University Medical Center, discussed how amyloidosis can impact the gastrointestinal tract, GI symptoms, and symptom management.

The webinar concluded with a Q and A session.

Original Presentation Date:
July 22, 2024

Download Dr. Horst’s Slides →

0:00 — Intro
3:35 — Amyloidosis & GI Symptoms
7:05 — Diagnosis
12:26 — VUMC Experiences

14:51 — Treatment Overview
16:27 — Upper GI Symptom Treatment
20:07 — Diarrhea Treatment
24:24 — SIBO Treatment (Small Intestinal Bacterial Overgrowth)
26:09 — Constipation Treatment
27:33 — Other Symptom Treatment
28:28 — Dietary Interventions
35:12 — Summary

35:50 — Q&A Session
36:45 — Can Vyndamax (tafamidis) help with GI symptoms?
37:56 — Can diet affect long-term amyloid deposition?
39:37 — When should I treat constipation, and how should I treat it?
41:47 — Should I worry about cardiac side effects while using Imodium (loperamide)?
42:34 — Does Ozempic (semaglutide) affect amyloidosis?
43:33 — How do I manage low calcium or low iron?
45:22 — How do I manage gas/bloating and reflux?
47:26 — Can amyloidosis be diagnosed by GI symptoms alone?
48:25 — How do I test for SIBO or pancreatic insufficiency?
49:15 — Do you recommend probiotics?
50:14 — Should I try to find amyloid in my GI tract through medical imaging?
51:34 — How can I tell if nutrients are being digested properly?
52:32 — How do I manage alternating constipation and diarrhea?
55:46 — Is there any connection between amyloidosis and hemorrhoids?

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