Dr. Melissa Hershman joined ARC to discuss how amyloidosis may be affecting your gut, and what you can do about it. There was also an opportunity for questions and answers.
Original Presentation Date:
March 18, 2026
0:00 — Welcome
3:58 — Introduction
5:15 — Epidemiology of GI Involvement in Amyloidosis
7:16 — How GI Symptoms Present in Amyloidosis
9:08 — Amyloidosis Overview
11:28 — Main Mechinisms for GI Involvement
13:40 — Mucosal Involvement
15:26 — Vascular Involvement
17:52 — Neuromuscular Involvement
19:14 — Testing Overview
22:21 — GI Symptoms in Amyloidosis
32:37 — Small Intestinal Bacterial Overgrowth (SIBO)
34:49 — Treatment Overview
36:20 — GERD (refulx)
40:11 — Gastroparesis & Nausea
46:10 — Diarrhea
49:53 — SIBO
51:00 — Constipation
52:37 — Pelvic Floor Dysfunction
53:49 — Abdominal Cramping
54:42 — Q&A Session
54:54 — How strong is the evidence for accupuncture for helping with GI symptoms?
55:35 — Can probiotics help with gut management?
56:59 — Are there treatments for fecal incontinence?
58:04 — Is my dry mouth, stomach cramping, and constipation normal or a side effect of my medication?
58:49 — My gastroenterologist isn’t familiar with amyloidosis. How can I help them?
1:00:02 — How do I distinguish between amyloidosis symptoms and side effects of taking Ozempic (semaglutide)?
1:01:07 — When should I see a gastroenterologist? Is it beneficial to also work with a dietitian?
1:03:00 — What is gastroparesis? How does it affect the body?
1:04:00 — Conclusion
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