Month: June 2022

BREAKING NEWS: The U.S. Food and Drug Administration today approved Alnylam Pharmaceuticals AMVUTTRA^TM, a novel therapy for the treatment of hereditary transthyretin (hATTR) amyloidosis with polyneuropathy. This approval comes after positive results from the readout of HELIOS-A Phase III study in which patients on the RNAi therapeutic met all secondary endpoints measured at 18 months.

“Hereditary ATTR amyloidosis is an aggressive, debilitating, and often fatal disease,” says Michael Polydefkis, Director of the Cutaneous Nerve Lab and Professor of Neurology at John Hopkins. “The data supporting treatment with AMVUTTRA^TM in patients with hATTR polyneuropathy is extensive, demonstrating the drug’s ability to improve neuropathy impairment, quality of life, functional status and performance in patients. This builds upon the groundbreaking efficacy of patisiran, which was the first siRNA therapy approved for any disease.”

AMVUTTRA^TM is classified as a gene-silencer, aiming to inhibit production of the transthyretin (TTR) protein in the liver, thereby reducing the levels of TTR in the body, preventing amyloid build-up and organ damage.

What sets AMVUTTRA^TM apart from the currently available gene-silencers is its frequency and route of dosing; AMVUTTRA^TM is a subcutaneous injection given every 3 months, whereas Onpattro® is administered by infusion every three weeks and Tegesdi® is a once-weekly subcutaneous injection.

“The therapeutic landscape of amyloidosis treatments is changing quickly and expanding rapidly,” says Isabelle Lousada, ARC CEO. “Only a few short years ago, patients with hATTR had limited treatment options, without a single drug approved in the United States. The approval of AMVUTTRA^TM marks the third drug approval for patients with hATTR polyneuropathy within the past few years, and an important step towards granting patients additional treatment options. The quarterly, subcutaneous injections make it an appealing treatment option, as it may be more compatible with the everyday lives of some patients.”

Following FDA approval, AMVUTTRA^TM can be prescribed for treatment of hATTR polyneuropathy once Alnylam Pharmaceuticals completes their preparations to bring the drug to market.

AMVUTTRA^TM is also being studied in patients with cardiac ATTR amyloidosis. The study which is ongoing is called HELIOS-B and is investigating vutrisiran for ATTR patients with cardiomyopathy (both hereditary and wild-type). Results for HELIOS-B are not expected for another couple of years.

View more information about AMVUTTRA^TM info sheet here.

Read more about hereditary ATTR amyloidosis here.

Read original press release here.