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Dr. Melissa Hershman joined ARC to discuss how amyloidosis may be affecting your gut, and what you can do about it. There was also an opportunity for questions and answers.

Original Presentation Date:
March 18, 2026

0:00 — Welcome

3:58 — Introduction

5:15 — Epidemiology of GI Involvement in Amyloidosis

7:16 — How GI Symptoms Present in Amyloidosis

9:08 — Amyloidosis Overview

11:28 — Main Mechinisms for GI Involvement

13:40 — Mucosal Involvement

15:26 — Vascular Involvement

17:52 — Neuromuscular Involvement

19:14 — Testing Overview

22:21 — GI Symptoms in Amyloidosis

32:37 — Small Intestinal Bacterial Overgrowth (SIBO)

34:49 — Treatment Overview

36:20 — GERD (refulx)

40:11 — Gastroparesis & Nausea

46:10 — Diarrhea

49:53 — SIBO

51:00 — Constipation

52:37 — Pelvic Floor Dysfunction

53:49 — Abdominal Cramping

54:42 — Q&A Session

54:54 — How strong is the evidence for accupuncture for helping with GI symptoms?

55:35 — Can probiotics help with gut management?

56:59 — Are there treatments for fecal incontinence? 

58:04 — Is my dry mouth, stomach cramping, and constipation normal or a side effect of my medication?

58:49 — My gastroenterologist isn’t familiar with amyloidosis. How can I help them?

1:00:02 — How do I distinguish between amyloidosis symptoms and side effects of taking Ozempic (semaglutide)?

1:01:07 — When should I see a gastroenterologist? Is it beneficial to also work with a dietitian? 

1:03:00 — What is gastroparesis? How does it affect the body?

1:04:00 — Conclusion

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